Eva Gruden, mag. farm., PhD
Področja:
Na svoji raziskovalni poti sem se navdušila nad raznovrstnostjo in večplastnostjo imunskih celic – eozinofilcev, ki so udeleženi pri nastopu alergijskih obolenj. Trenutno preučujem eozinofilce v klinični študiji pacientov z redkim obolenjem požiralnika – eozinofilnim ezofagitisom.
Eva Gruden (Knuplez)
Professional experience:
april 2021- Postdoctoral researcher/ University asisstent
Division of Pharmacology, Otto Loewi Research Center,
Medical University of Graz (PI: Dr. Rudolf Schicho)
2016-2021 PhD candidate
Division of Pharmacology, Otto Loewi Research Center,
Medical University of Graz (PI: Dr. Gunther Marsche)
International PhD programme Molecular Fundamentals of
Inflamation (DK-Molin)
2019 Research stay abroad Feinberg School of Medicine,
Northwestern University, Chicago, USA;
(PI: Dr. Bruce Bochner, MD)
2015-2016 Student work in regulatory affairs
LEK d.d – a Sandoz company, Ljubljana, Slovenia
2014-2015 Pharmacy internship Ljubljana University Medical Centre
2014 Student researcher Animacel Biotehnologija d.o.o, Ljubljana
2012-2014 European Pharmaceutical Students ́Association liason
AWARDS:
2019 Austrian Marshall Plan Foundation Scholarship
(research visit to Northwestern University in Chicago
2019- ÖGMBT travel grant
2018 FEBS Journal Poster prize
2016 Faculty Prešeren award for research excellence
2016 Faculty award for best students (GPA 9/10)
2006-2016 Zois scholarship for gifted students
PUBLICATIONS (1st author):
Knuplez E, Sturm EM, Marsche G. Emerging role of phospholipase-derived cleavage products in
regulating eosinophil activity: focus on lysophospholipids, polyunsaturated fatty acids
and eicosanoids. Int. J. Mol. Sci. 2021, 22, doi:10.3390/ijms22094356.
Knuplez E, Kienzl M, Trakaki A, Schicho R, Heinemann A, Sturm EM, Marsche G. The anti-parasitic
drug miltefosine suppresses human eosinophil activation and ameliorates murine allergic inflammation
in vivo. Br J Pharmacol. 2021 Mar;178(5):1234-1248. doi: 10.1111/bph.15368.
Knuplez E, Marsche G. An Updated Review of Pro- and Anti-Inflammatory Properties of Plasma
Lysophosphatidylcholines in the Vascular System. Int J Mol Sci. 2020 Jun 24;21(12):4501.
doi: 10.3390/ijms21124501.
Knuplez E, Curcic S, Theiler A, Bärnthaler T, Trakaki A, Trieb M, Holzer M, Heinemann A, Zimmermann R,
Sturm EM, Marsche G. Lysophosphatidylcholines inhibit human eosinophil activation and suppress
eosinophil migration in vivo. Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Jul;1865(7):158686.
doi: 10.1016/j.bbalip.2020.158686.
Knuplez E, Krier-Burris R, Cao Y, Marsche G, O’Sullivan J, Bochner BS. Frontline Science: Superior
mouse eosinophil depletion in vivo targeting transgenic Siglec-8 instead of endogenous Siglec-F:
Mechanisms and pitfalls. J Leukoc Biol. 2020 Jul;108(1):43-58. doi: 10.1002/JLB.3HI0120-381R.
